Calcium current inactivation in denervated rat skeletal muscle fibres.
نویسندگان
چکیده
منابع مشابه
Denervated muscle fibres in hereditary mouse dystrophy.
Muscular dystrophy in the mouse, as in man, is considered to be a genetically determined primary myopathy in which abnormalities of motor innervation are secondary to degeneration of muscle fibres (cf. Harman, Tassoni, Curtis, and Hollinshead, 1963). In the mouse, however, there is now evidence to indicate that the motor nerve supply to a fibre may be affected at a stage in the disease when the...
متن کاملThree components of calcium currents in crayfish skeletal muscle fibres.
The coexistence of multiple types of calcium currents within the same cell has been demonstrated in voltage clamp experiments in several cells (for review see Hagiwara et Byerly 1981). Single channel recordings confirmed the existence of distinct electrical and pharmacological properties of Ca channels and, based on these differ ences, three types of Ca channels were characterized (classified)...
متن کاملCalcium binding protein changes of sarcoplasmic reticulum from rat denervated skeletal muscle.
Two Ca2+ sequestering proteins were studied in fast-twitch (EDL) and slow-twitch (soleus) muscle sarcoplasmic reticulum (SR) as a function of denervation time. Ca2+-ATPase activity measured in SR fractions of normal soleus represented 5% of that measure in SR fractions of normal EDL. Denervation caused a severe decrease in activity only in fast-twitch muscle. Ca2+-ATPase and calsequestrin conte...
متن کامل"Current" advances in mechanically skinned skeletal muscle fibres.
1. In skeletal muscle, excitation-contraction (E-C) coupling describes a cascade of cellular events initiated by an action potential (AP) at the surface membrane that ultimately results in muscle contraction. Being able to specifically manipulate the many processes that constitute E-C coupling, as well as the many factors that modulate these processes, has proven challenging. 2. One of the simp...
متن کاملElectron microscopic study of long-term denervated rat skeletal muscle.
BACKGROUND This study describes the ultrastructure of long-term denervated rat extensor digitorum longus and tibialis anterior muscles, with particular emphasis on understanding the cellular basis for the reduced restorative capacity of long-term denervated muscle. METHODS In 30 male WI/HicksCar rats, the right hindleg was denervated for periods of 1, 2, 4, 5.5, 6, 7, 12, 14, and 18 months be...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1993
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1993.sp019465